Nifedipine-phenytoin interaction

Fatal phenytoin warfarin interaction.

Digoxin-phenytoin interaction.

Tolerance of Rifampicin SIR,-One of the virtues of rifampicin is said to be a good patient tolerance which, as you have noted (30 August, 1969, p. 487), should be particularly valuable in treatment of tuberculosis where tolerance is poor. To demonstrate objectively whether this good tolerance extends to domiciliary ambulant therapy we have used a simple urine test for rifampicin on patients att...

Phenytoin induced chorea in a pediatric patient: An interaction between phenytoin, phenobarbital and clobazam

A 3-year-old female patient developed chorea possibly due to an interaction between phenytoin, phenobarbital and clobazam used for generalized tonic clonic seizures. Phenytoin withdrawal resulted in recovery within 24 hours. Post reaction computerized tomography (CT)-scan of brain was normal. Combined use of anti-seizure drugs and interactions between them may be responsible for the reaction. T...

Evidence of an interaction between nifedipine and nafcillin in humans.

AIMS Nafcillin (Wyeth Laboratories, Philadelphia, PA, USA) has been reported to induce the metabolism of cyclosporin and warfarin, which are known substrates of cytochrome P-450 (CYP). However, there has not been any report to date on its possible interaction with nifedipine, an index substrate of the enzyme, CYP3A4. METHODS Nine healthy normotensive subjects participated in this randomized p...

Epidemiological analysis of nifedipine and phenytoin-induced gingival overgrowth in users of the Primary Health Care System

Methods: Demographic, pharmacological, and periodontal data were obtained from 100 users of the Brazilian Primary Health Care System in Diamantina, Jequitinhonha Valley, Minas Gerais state, Brazil, who were taking nifedipine and/or phenytoin. Clinical evaluations including gingival overgrowth analysis were carried out by a single calibrated examiner. Bivariate analysis (Chi-square test or Stude...